Fig. 4

Podocyte-specific knockout of PP2A results in foot process effacement. a Transmission electron microscope illustrates foot process effacement at 3 weeks, 5 weeks and 8 weeks of age. Scale bar: 2 μm. b Scanning electron microscope illustrates the dramatic loss of podocyte foot process interdigitation and destruction of the major processes in Pod-PP2A-KO mice at 5 weeks of age. Scale bars: 2 μm. c High-magnification micrographs shows foot process effacement in glomeruli from Pod-PP2A-KO mice at 5 weeks of age. Scale bars: 1 μm. d Quantification of the number of podocyte foot processes per μm of glomerular basement membrane in Pod-PP2A-KO mice at 3 weeks, 5 weeks and 8 weeks of age. n = 2 mice at each time point