Fig. 3
From: Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice
Podocyte-specific loss of PP2A results in progressive glomerulosclerosis and interstitial fibrosis. a Representative HE images of glomeruli from Pod-PP2A-KO mice revealing histological evidence of dilated glomerular capillary loops at 5 weeks of age (arrowheads), which progresses to diffuse glomerulosclerosis by 8 weeks. Scale bar: 50 μm. b Proteinaceous casts (arrowhead) and severe interstitial fibrosis are observed in kidney section from Pod-PP2A-KO mice at 8 weeks of age by the HE, Masson, and PAS staining. Scale bar: 50 μm