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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer

Fig. 4

Leucine transport is dependent on EGF-stimulated PI3K/Akt signalling. a and b, Akt and P70S6K activation was examined in the presence of rapamycin and LY294002 in LNCaP (a) or PC-3 cells (b). GAPDH was used as loading control. All western blot images are representative of three independent experiments. c and d, leucine transport was examined in the presence of rapamycin or LY294002 in LNCaP (c) and PC-3 cells (d). Two-tailed student’s t-test was performed. Data are the mean ± SEM, n = 3

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