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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: OMICs approaches-assisted identification of macrophages-derived MIP-1γ as the therapeutic target of botanical products TNTL in diabetic retinopathy

Fig. 6

MIP1γ/CCR1 axis in retina endothelial cells contributed to the ameliorative effect of TNTL on endothelial dysfunction. a. showed that CCR1 downstream signalings in RECs cultured with SN from TNTL-treated BMDMs were blunted; b. showed that transcription of migration/invasion-associated genes was not activated in RECs cultured with SN from TNTL-treated BMDMs; c. showed that MIP1γ-induced RECs migration was blocked by the presence of CCR1 antagonist J-113863 (100 nM); d. showed that MIP1γ-induced loss of RECs monolayer integrity was blocked by the presence of CCR1 antagonist J-113863 (100 nM); e. showed MIP1γ-induced FITC-Dextran leakage through RECs monolayer was blocked by the presence of CCR1 antagonist J-113863 (100 nM). *p < 0.05, **p < 0.01, ***p < 0.001 when compared with model group

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