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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: OMICs approaches-assisted identification of macrophages-derived MIP-1γ as the therapeutic target of botanical products TNTL in diabetic retinopathy

Fig. 4

Suppression of pro-inflammatory macrophages by TNTL improved the endothelial condition in retina. a. showed that TNTL treatment could significantly reduce the infiltration and residence of F4/80+ macrophages; b. showed that supernatant (SN) from TNTL-treated pro-inflammatory BMDMs had minimal effect on the cell viability of retinal endothelial cells (RECs); c. showed that SN from TNTL-treated pro-inflammatory BMDMs failed in inducing RECs migration; d. showed that SN from TNTL-treated pro-inflammatory BMDMs induced loss of monolayer integrity formed by RECs; e. showed that SN from TNTL-treated pro-inflammatory BMDMs led to the leakage of FITC-Dextran through RECs monolayers. *p < 0.05, **p < 0.01, ***p < 0.001 when compared with model group

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