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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: OMICs approaches-assisted identification of macrophages-derived MIP-1γ as the therapeutic target of botanical products TNTL in diabetic retinopathy

Fig. 3

The inhibitory effect of TNTL on DR involves anti-inflammatory action. a. showed the heatmap of gene expression in the retina of hyperglycemia mice that were significantly changed after TNTL treatment; b. showed that volcano plot of gene expression profile. The green dots indicate genes with expression down-regulated by TNTL; red dots indicate genes with expression up-regulated by TNTL; while grey dots stand for genes without significant change in expression; c. showed the GO analysis on the involvement of main biological process (BP), cellular component (CC), and molecular function (MF) of common genes. The red asterisk indicated the GO items related to inflammation regulation; d. showed the KEGG pathway analysis on the common genes. e. showed the involvement of protein-protein interaction networks; f. showed GSEA analysis on the significantly changed gene-sets of cytokine-cytokine receptor interaction. It was revealed that TNTL treatment was negatively related to the identified gene sets

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