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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Histone deacetylase 1 induced by neddylation inhibition contributes to drug resistance in acute myelogenous leukemia

Fig. 4

HDAC inhibition decreased doxorubicin resistance of HL-60/ADM, K562/A02 and primary BMCs in refractory AML. a doxorubicin-releasing index of AML cells after treatment with AR-42, an inhibitor of HDACs. b doxorubicin-releasing index of AML cells after treatment with Panobinostat, another inhibitor of HDACs. c doxorubicin-releasing index of AML cells after treatment with SNDH-275, a specific inhibitor of HDAC1. d MRP1 protein expression was detected by western blot. Data are the mean ± SD of three independent experiments in AML cells. **P < 0.01 vs. control

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Cell Communication and Signaling

ISSN: 1478-811X