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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Histone deacetylase 1 induced by neddylation inhibition contributes to drug resistance in acute myelogenous leukemia

Fig. 3

Effect of HDAC1 knockdown on doxorubicin resistance of HL-60/ADM, K562/A02, and primary BMCs of refractory AML. a Relative cell viability of si-HDAC1 transfected AML cells after different doses of doxorubicin treatment. b Percentage of apoptotic cells in si-HDAC1 transfected AML cells after doxorubicin (0.01 μg/ml) treatment. c doxorubicin-releasing index of si-HDAC1 transfected AML cells. d MRP1 protein expression in si-HDAC1 transfected AML cells. DOX, doxorubicin. Data are the mean ± SD of three independent experiments in AML cells. *P < 0.05, **P < 0.01 vs. si-control

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