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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Histone deacetylase 1 induced by neddylation inhibition contributes to drug resistance in acute myelogenous leukemia

Fig. 2

Effect of HDAC1 overexpression on doxorubicin resistance of HL-60, K562, and primary BMCs of remission AML. a Relative cell viability of pcDNA-HDAC1 transfected AML cells after different doses of doxorubicin treatment. b Percentage of apoptotic cells in pcDNA-HDAC1 transfected AML cells after treatment with 0.1 μg/ml of doxorubicin. c doxorubicin-releasing index of pcDNA-HDAC1 transfected AML cells. d MRP1 protein expression in pcDNA-HDAC1 transfected AML cells. P, pcDNA; H, pcDNA-HDAC1. DOX, doxorubicin. Data are the mean ± SD of three independent experiments in AML cells. *P < 0.05, **P < 0.01 vs. pcDNA

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