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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways

Fig. 7

A schematic diagram illustrates the molecular mechanism of SAE1-induced glioma progression. SAE1 overexpression induces increase of the SUMOylation and Ser473 phosphorylation of AKT, which regulates cell cycle distribution and cell biological behaviors including cell proliferation, migration and cell apoptosis, these finally accelerate the occurrence and development of glioma.:SUMOylation;: Phosphorylation

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