Fig. 9
From: ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms
MPNSTs are sensitive to knockdown of specific erbB4 activated signaling molecules. a-c) Cell proliferation was assessed in three log phase MPNST cell lines in the presence of multiple designated PLCγ(a), STAT3 (b), or STAT5 (c) shRNA’s or non-targeting controls. Values represent cell number over 5 days of shRNA knockdown normalized to 0 h. PLC-γ inhibition effects cell proliferation in a cell-type dependent manner (a). STAT3 inhibition significantly affects cell proliferation (b). STAT5 inhibition significantly affects cell proliferation (c)