Fig. 6
From: ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms
RNA-Seq pathway analysis of differentially affected genes in erbB4 knockout UBI MPNST cells. Partek analysis of NextGen RNA sequencing identified differentially expressed genes. Genes with a fold change of at least 1.5 up or down were put through Panther gene over representation enrichment analysis to identify erbB4 affected signaling pathways (a) and molecular function activity (b). Graphs represent the ratio of over-represented genes differentially affected by erbB4 loss compared to expected reference representation. This analysis highlights the role of erbB4 in migration, angiogenesis and PLCγ signaling