Fig. 5
From: ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms
Erbb4 is not essential for Ras hyperactivation. a A comparison of Ras activation in Erbb4-null (Cre) and Erbb4-expressing control (Ctl) UBI 1–3 MPNST cells shows that Erbb4 loss does not affect Ras activation. b Immunocytochemistry staining of Erbb4-null (Cre) and Erbb4-expressing control (Ctl) UBI MPNSTs cells displays reduced erbB4 expression in adeno-viral infected cells (GFP positive). Representative erbB4 staining of control erbB4 positive tumors (Ctl) and erbB4 negative tumors (Cre) with Bisbenzimide counterstain for cell nuclei detection. A non-immune isotype matched primary was used as a negative control. Images were acquired at 20X. Scale bars represent 100 um