Fig. 3
From: ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms
Erbb4 ablation inhibits allograft growth and alters tumor histopathology in Nude mice. a and b) Erbb4-null cells from three separate tumor lines show reduced graft volume (a) and mass (b) compared to erbB4 expressing controls. p-values ≤0.05 are designated with an asterisk (*), Tumor mass p-values are as follows: UBI-1: 0.049, UBI-2: 0.069, and UBI-3: 0.005; F-Test. c Representative histologic images of a UBI GFP control tumor and a UBI Cre tumor taken at 40X. Arrows in Ctl indicate the multinucleated cells that are commonly seen in these tumors. Note that these multinucleated cells are virtually absent in the Erbb4-null grafts. d Representative chromogenic erbB4 stained images of UBI GFP control tumor and UBI Cre tumors displaying decreased erbB4 expression in Cre ablated xenografts compared to control tumors taken at 20X