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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

Fig. 7

Involvement of peripheral CCK-BR activation in pain hypersensitivity. a,b intraplantar injection (i.p.l.) of CCK-8 (50 ng) induced mechanical (a) and heat (b) pain hypersensitivity. *p < 0.05, **p < 0.01, CCK-8 injection vs. vehicle. c, d pretreatment of LY225910 (0.5 μg, i.p.l., c), but not devezepide (1 μg, i.p.l., d), significantly attenuated CCK-8-induced mechanical hypersensitivity and thermal hyperalgesia. e, f intraplantar pre-injection of 4-AP (25 nmol) occluded the thermal and mechanical hypersensitivity induced by CCK-8 (50 ng). *p < 0.05, **p < 0.01, CCK-8 injection vs. vehicle; + p < 0.05 and ++ p < 0.01, CCK-8 injection vs. CCK-8 + devazepide (Dev.) at 45 min; #p < 0.05 and ##p < 0.01, 4-AP injection vs. vehicle at 45 min. N = at least 8 mice for all animal behavior experiments

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