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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Minocycline impairs TNF-α-induced cell fusion of M13SV1-Cre cells with MDA-MB-435-pFDR1 cells by suppressing NF-κB transcriptional activity and its induction of target-gene expression of fusion-relevant factors

Fig. 3

TNF-α induced cell fusion is not affected by ERK1/2, p38, JNK, SRC or AP-1 inhibition. Cell fusion was carried out in the presence of 100 ng/ml TNF-α and different concentrations of selective inhibitors. a Data for SP600125 (SP; JNK inhibitor), PD98059 (PD; Erk1/2 inhibitor) and SB202190 (SB; p38 inhibitor). b Results for PP1 (SRC inhibitor) and SR (SR11302; AP-1 inhibitor). The results are presented as the means ± STD of at least three independent experiments. Statistical analysis: ANOVA F-test and Scheffé post hoc test: * = p < 0.05; ** = p < 0.01; *** = p < 0.001

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