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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

Fig. 3

Ectopic WWOX, TIAF1, and p53 suppress cell migration and anchorage-independent cell growth. a, b Cells were introduced with indicated mammalian plasmids by electroporation. Transient overexpression of WWOX, TIAF1, and/or p53 inhibited the migration of MDA-MB-231 and MCF-7 cell (Mean ± S.D., n = 3, student’s t test). c Colocalization of transiently overexpressed TIAF1 with p53 and WWOX proteins in MDA-MB-231 cells. d, e In anchorage-independent cell growth, ectopic WWOX, TIAF1 and p53, in combination, dramatically suppressed colony formation of MDA-MB-231. EP, electroporation only. f Western blot analysis demonstrated the expressed protein profile in COS7 cells

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