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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization

Fig. 8

KBP increases the production of M-CSF and MCP-1, which employs the differentiation and migration of monocytes and macrophages. a The plasma level of M-CSF in WT and KBP-TG mice. b The level of M-CSF in the cell supernatant of RAW 264.7 cells. c The mRNA expression of M-CSF in RAW264.7 cells treated with KBP versus that in the Con group. d KBP stimulates the migration of macrophages. Representative images of the Transwell migration assay and a statistical histogram. e The mRNA expression of MCP-1 in the wounds of WT and KBP-TG mice at different time points. f The mRNA expression of MCP-1 in the wounds of DM mice treated with IgG and KBP antibody at different time points. g The plasma level of MCP-1 in WT and KBP-TG mice. h The level of MCP-1 in the cell supernatant of RAW264.7 cells treated with KBP versus that in the Con group. The supernatant of RAW264.7 cells treated with KBP versus that of the Con group. I. The mRNA expression of MCP-1 in RAW264.7 cells treated with KBP versus that in the Con group. Data are presented as the mean ± SD. n = 3; * p < 0.05

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