Fig. 7

KBP stimulates the M1 polarization of macrophages via cross-activation of the Notch and NF-κB signalling pathways. a Bioinformatics prediction via the PROMO website of the possible transcription factors that bind to the iNOS promoter region. b The expression of iNOS and molecules in the NF-κB signalling pathway in RAW264.7 cells treated with KBP with or without JSH23. c The expression of NF-κB p65 in the cytoplasm of RAW264.7 cells. d The expression of NF-κB p65 in the nuclei of RAW264.7 cells. e The expression of CYLD, iNOS and molecules in the NF-κB signalling pathway in RAW264.7 cells treated with KBP with or without DAPT. f The expression of CYLD, iNOS and molecules in the NF-κB signalling pathway in RAW264.7 cells transfected with Hes1 or control vector. Three independent experiments were employed