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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization

Fig. 4

KBP promotes the M1 polarization of macrophages in vivo. a, b Representative images showing immunofluorescent staining of wound tissue sections of WT and DM mice at D10. c, d Representative images showing immunofluorescent staining of wound tissue sections of WT and KBP-TG mice at D10. e, f Representative images showing immunofluorescent staining of wound tissue sections of DM mice treated with IgG or KBP antibody at D10. (A-F) Scale bar = 50 μm. F4/80: macrophage marker, iNOS: M1 marker, ARG1: M2 marker. g, h The mRNA expression of iNOS and ARG1 in the wounds of WT and KBP-TG mice at different time points. i, j The expression of iNOS and ARG1 in the wounds of diabetic mice treated with IgG or KBP antibody. Data are presented as the mean ± SD. n = 3; * p < 0.05

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