Table 2 The lncRNAs that regulate hTERT
From: Diverse regulatory manners of human telomerase reverse transcriptase
LncRNA | Effects on hTERT/telomerase | Mechanism | Human cell model | Ref. |
|---|---|---|---|---|
hTAP-AS | hTERT expression ↓ | not stated | embryonic kidney cells | [142] |
HOTAIR | positive effect on hTERT in respond to estrogen | regulates the estrogen target genes positively by estrogen-modulated chromatin remodeling | prostate cancer cells | [143] |
MALAT1 | hTERT transcription ↓ | functions on hTERT promoter | prostate cancer cells | [143] |
CDKN2B-AS1 | hTERT expression ↓ | not stated | esophageal squamous carcinoma cells | [144] |
BC032469 | hTERT expression ↑ | functions as a sponge for miR-1207-5p | gastric cancer cells | [145] |
TERRA | functions as a telomerase ligand and direct telomerase inhibitor | TERRA base repeats pair with hTERC, TERRA contacts with hTERT protein | embryonic kidney cells | [147] |
CUDR | the binding of hTERT/hTERC ↑ the binding of hTERT/TERRA ↓ telomerase activity ↑ | the CUDR-CyclinD1 complex enhances the expression of H19 | liver cancer stem cells | [146] |
hsa_circ_0020397 | hTERT expression ↑ | inhibits miR-138 activity and its targets | colorectal cancer cells | [148] |