Fig. 5
From: Neuropilin-1 drives tumor-specific uptake of chlorotoxin
Knockout of NRP1 in PC-3 tumors blunts the antitumor effect of ER-472 through reducing active metabolite uptake into tumors. Subcutaneous tumors were established in NOD SCID mice; treatment groups were n = 5 or 6 and treatment schedule was Q4Dx3 (dosing days denoted with long ticks on x-axis). Tumor volume data represents the mean ± SEM. Differential sensitivity of PC-3 NRP1 WT versus KO xenografts to treatment with ER-472 (a) compared to ER-271 (b). **P ≤ 0.01, ***P ≤ 0.001, one-way ANOVA followed by Tukey’s multiple comparison test; n.s. = not significant. c, mean active metabolite (S-methyl cryptophycin) tumor concentration versus time profiles following a single dose of ER-472 at 0.6 mg/kg (¼ MTD). Data represents the mean ± StdDev. ****P ≤ 0.0001, unpaired t-test