Fig. 2
From: Neuropilin-1 drives tumor-specific uptake of chlorotoxin
ER-472 antitumor activity and levels of active metabolite in 3 xenograft models; MIA PaCa-2, BxPC-3 and PC-3. Subcutaneous tumors were established in nude mice; treatment groups were n = 6 for MIA PaCa-2 and BxPC-3 and n = 5 for PC-3 efficacy studies and n = 3 for all metabolite studies. a, ER-472 was administered i.v. Q4Dx3 (dosing days denoted with long ticks on x-axis). Tumor volume data represents the mean ± SEM. b, mean active metabolite (S-methyl cryptophycin) tumor concentration versus time following a single dose of ER-472 at 2.5 mg/kg (MTD). Data represents the mean ± StdDev. c, antitumor activity of ER-472 versus ER-271 at molar equivalent (ME) dose in PC-3 model. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, one-way ANOVA followed by Tukey’s multiple comparison test; n.s. = not significant