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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Estrogen receptor α-NOTCH1 axis enhances basal stem-like cells and epithelial-mesenchymal transition phenotypes in prostate cancer

Fig. 6

The total signaling pathway. ERα-induced estrogen effects promoted the expression of NOTCH1 by binding NOTCH1 promoter at − 1364 and − 1188 bp, EZH2 was recruited by ERα and acts as a cofactor to assist ERα-induced estrogen effects in regulating NOTCH1 in PCa. The ERα-induced estrogen effects may promote CD49fHi EMT-PCBSLCs metastasis to other organs

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