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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways

Fig. 8

Ori exerted anti-inflammatory effects via Nrf2-independent pathways. WT and Nrf2−/− mice were given an intraperitoneal administration of Ori (20 and 40 mg/kg) 1 h prior to an intranasal administration of LPS. a Representative histological section of the lungs was stained by hematoxylin and eosin (H&E staining, magnification × 200). b Protein expressions of Nrf2, HO-1, NLRP3, ASC, CASPASE-1, IL-1β, p- IκBα and IκBα were measured by Western blot analysis. c Quantification of expressions of previous protein was performed by densitometric analysis, and β-actin acted as an internal control. All results were expressed as the means ± SEM of three independent experiments. *p < 0.05 and **p < 0.01 versus the control group, #p < 0.05 and ##p < 0.01 versus LPS group

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