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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Cancer-associated fibroblasts in radiotherapy: challenges and new opportunities

Fig. 1

Radiation causes a series activation process in tumor microenvironment (TME) including cycling hypoxia, immune modulation, vascular regeneration, inflammation and fibrosis. Radiation therapy induces fibroblast into senescence-like fibroblasts, which share similar characteristics with activated fibroblasts. These cells work together to remodeling the TME. High levels of TGF-β1 was detected in conditioned media from irradiated fibroblasts, which promoted their self-activation. The altering gene expression in radiation treated fibroblasts are mainly focus on cell cycle arrest, DNA repair, ROS scavenging, ECM remodeling, Wnt signaling and IGF signaling

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