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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway

Fig. 7

Inhibition of Activin A pathway ameliorated fibrosis in endometriosis mice. Endometriosis was induced in BALB/c mice. The mice were were randomly assigned to four experimental groups (n = 7) and received a daily intraperitoneally injection of recombinant mouse Activin A (0.7 μg/mouse), αActivin A, a neutralizing antibody of Activin A, (3 μg/mouse), Activin A (0.7 μg/mouse) + αActivin A (3 μg/mouse) and saline, respectively, for 4 weeks. Then the mice were sacrificed and the endometriotic lesions were harvested. a The collagen deposits and the expression of CTGF, α-SMA, collagen I and fibronectin in ectopic endometria were detected by Masson trichrome staining and immunohistochemistry, respectively. b Relative extent of fibrosis and mean optical density were determined by Image ProPlus. **P < 0.01 and ***P < 0.001 versus the control group, respectively

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