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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway

Fig. 3

CTGF is essential for Activin A-induced expression of collagen I, α-SMA and fibronectin in endometrial MSCs. a Eutopic endometrial MSCs derived from patients without endometriosis (n = 3) were treated with recombinant human Activin A (25 ng/mL) and/or recombinant human CTGF (25 ng/mL) for 3 h. mRNA expression levels of CTGF, ACTA2, COL1A1 and FN1 were analyzed by q-PCR. The data were presented as means ± SD. **P < 0.01 and ***P < 0.001versus the cells treated neither Activin A nor CTGF, respectively. b Eutopic endometrial MSCs derived from patients without endometriosis (n = 3) were transfected with control shRNA (shNC) or shRNA targeting CTGF (shCTGF) and treated with 25 ng/mL recombinant human Activin A for 3 h. mRNA expression levels of CTGF, ACTA2, COL1A1 and FN1 were analyzed by q-PCR. The data were presented as means ± SD. *** represents P < 0.001

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Cell Communication and Signaling

ISSN: 1478-811X