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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Cold atmospheric plasma and silymarin nanoemulsion synergistically inhibits human melanoma tumorigenesis via targeting HGF/c-MET downstream pathway

Fig. 5

Dual effect of SN (100 nM) and CAP (180 s) assisting with the inhibition of the melanoma-specific HGF/c-MET pathway and its markers in G-361 cells. (a) Diagrammatic representation of the co-effect of SN and CAP to induce apoptosis of the HGF/c-MET pathway. (b) Western blot showing the phosphorylation and total status of c-MET and AKT at Tyr1230, S473 and T308 and phosphorylation and the total BRAF level (c) The melanoma-specific protein BRAF level and (d) Cellular NAMPT was calculated using a flow cytometer. Student’s t-tests were performed, and the levels of significance are indicated as follows: *, p < 0.05; δ, p < 0.01; and #, p < 0.001

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