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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Fig. 8

TFEB relocates into the nucleus upon chronic induction of AAR by HF. a WRO cells plated on coverslips were treated or not with 100 nM halofuginone. After 8 and 24 h, the cells were fixed, processed for TFEB (green) immunostaining and imaged by confocal fluorescence microscopy. Nuclei were stained with DAPI. Scale bars: 10 μm. The images shown are representative of three separate experiments. b Bars indicate the average green + blue fluorescence intensity density of immunofluorescences shown in (a). Data are from five different images for each condition. Error bars: standard deviation. Statistically significant difference between fluorescence intensity densities after to before HF is shown (*, p ≤ 0.05)

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Cell Communication and Signaling

ISSN: 1478-811X