Fig. 7From: Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cellsProposed molecular mechanism for the regulation of FST by cav-1. In the absence of cav-1/caveolae, enhanced PI3K activity activates PKCζ which augments Sp1 phosphorylation, nuclear accumulation and activity. This increases Sp1 binding to the -123 bp region of the FST promoter, resulting in elevated FST transcriptional activation and protein expressionBack to article page