Cell Communication and Signaling

Table 1 The statistical analysis of NOV gene methylation pattern in different phases of CML

From: Imatinib independent aberrant methylation of NOV/CCN3 in chronic myelogenous leukemia patients: a mechanism upstream of BCR-ABL1 function?

CpG position		40	47	68	102	111	113	124	126	147
Me-CpG	Chronic	6/9 66.7%	2/9 22.2%	6/9 66.7%	4/9 44.4%	4/9 44.4%	6/9 66.7%	4/9 44.4%	6/9 66.7%	7/9 77.8%
P-value of Fisher’s exact test		0.7041	0.5908	0.1392	1.0000	1.0000	0.1157	0.7041	0.0403	0.0168
CpG position		153	163	179	199	211	224	246		Total
Me-CpG	Chronic	8/9 88.9%	7/9 77.8%	4/9 44.4%	6/9 66.7%	6/9 66.7%	7/9 77.8%	4/8 50.0%		87/143 60.8%
P-value of Fisher’s exact test		0.0468	0.0074	0.6870	0.1157	0.0173	0.1251	1.0000		0.0000
CpG position		40	47	68	102	111	113	124	126	147
Me-CpG	Accelerated	3/5 60.0%	4/5 80.0%	3/5 60.0%	3/5 60.0%	4/5 80.0%	2/5 40.0%	4/5 80.0%	5/5 100%	5/5 100%
P-value of Fisher’s exact test		1.0000	0.0058	0.6221	0.6424	0.3549	1.0000	0.1377	0.0032	0.0056
CpG position		153	163	179	199	211	224	246		Total
Me-CpG	Accelerated	5/5 100%	5/5 100%	4/5 80.0%	1/5 20.0%	4/5 80.0%	4/5 80.0%	4/4 100%		60/79 75.9%
P-value of Fisher’s exact test		0.0447	0.0032	0.1282	1.0000	0.0195	0.3295	0.0932		0.0000
CpG position		40	47	68	102	111	113	124	126	147
Me-CpG	Blastic	2/6 33.3%	4/6 66.7%	4/6 66.7%	4/6 66.7%	3/6 50.0%	4/6 66.7%	3/6 50.0%	5/6 83.3%	4/6 66.7%
P-value of Fisher’s exact test		0.3944	0.0138	0.3589	0.3944	1.0000	0.1735	0.6526	0.0132	0.1510
CpG position		153	163	179	199	211	224	246		Total
Me-CpG	Blastic	6/6 100%	6/6 100%	4/6 66.7%	2/6 33.3%	4/6 66.7%	4/6 66.7%	5/6 83.3%		64/96 66.7%
P-value of Fisher’s exact test		0.0209	0.0013	0.1735	1.0000	0.0434	0.3944	0.1602		0.0000

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