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Table 1 The targets and functions of FOXM1 during the development of pulmonary disease

From: The multifaceted roles of FOXM1 in pulmonary disease

Cell types

Direct targets

Regulatory role

Biological process

References

Alveolar epithelial cells

Cox-2

Activate

Prostaglandin synthesis Pulmonary inflammation

[44]

Stfpa Stfpb

Activate

Surfactant production Differentiation

[13]

Jnk1 Axin2

Activate

Canonical Wnt signaling

[14]

Airway epithelium cells

Spdef

Activate

Mucus production Differentiation

[65]

Clara cells

Sox-2 Scgb1a1

Activate

Differentiation

[67]

Cancer cells (epithelial origin)

TOPO-2a

Activate

DNA repair

[45]

STMN1

Activate

Metastasis

[32]

Snail1

Activate

EMT

[9]

MMP2

Activate

Metastasis

[37]

Vimentin MMP-9

Activate

EMT

[29, 58]

E-cadherin

Inhibit

EMT

[29, 58]

Twist

Activate

EMT

[47]

Ikbkb Nfkb2

Activate

NF-KB pathway

[24]

N-Myc Pttg1 Cdkn2a

Activate

JNK pathway

[24]

Endothelial cells

Ctnnb1(β-catenin)

Activate

Adherens junctions

[80]

Flk-1 FoxF1

Activate

Vascular formation Pulmonary inflammation

[46]

Sfrp1

Activate

Canonical Wnt signaling

[46]

Fibroblasts

RAD51 BRCA2

Activate

DNA repair

[92]

Epithelial cells

Clara cells

Tumor cells

Endothelial cells

Fibroblasts

Smooth muscle cells

Cyclin A Cyclin B

Cyclin D PLK1

Skp2 Cks1

Cdc25A Cdc25B

AURKB Survivin

CENPA CENPB

Activate

Cell cycle regulation

[10, 11, 91, 96]

Monocytes/Macrophages

CCR2 CX3CR1

Activate

Recruitment of macrophages/monocytes to induce pulmonary inflammation

[65]

Macrophages

HMMR (CD168)

Activate

Altered migratory cell behavior Pulmonary inflammation

[81, 82]

mDCs

GM-CSFR/CD86 MHCII

Activate

Antigen presentation

[65]

Neutrophils

Eotaxins (CCL11,24) CX3CL1

Activate

Chemoattraction

[65]