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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes

Fig. 8

Estrogen compensates for the loss of function resulting from β2AR-gene knockout in female LV apical myocytes. a current-voltage comparisons among Wt sham, Wt male, OVX, and OVX + E2 myocytes. (n = 6–10 cells/4 mice). b Effect of β2AR on mRNA expression of the L-type Ca2+ channel depends on the E2 environment. (n = 3 mice). c Influence of E2 on β2AR mRNA level. (n = 3 mice). *P < 0.05, **P < 0.01, ***P < 0.001. All data are presented as mean ± S.E.M

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