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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes

Fig. 6

β2AR-induced stress model in male myocytes. a, Contractile responses to β-adrenergic receptor stimulation by increasing concentration of isoproterenol (ISO) (n = 10 cells/4 mice) (b), Effect of epinephrine (Epi) stress on cardiac contraction. (n = 10 cells/4 mice). c Effects of stress on contraction amplitude abolished by β2AR knockout (β2KO) n = 10 cells/4 mice. d Effects of stress on Ca2+ transient amplitude were abolished by β2KO, n = 10 cells/4 mice. *P < 0.05, **P < 0.01, and ***P < 0.001. All data are presented as mean ± S.E.M

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