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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes

Fig. 5

Sex differences in basal mRNA expression of PLB, SLN, SERCA2a, and RyR2 are modulated by E2. GAPDH levels were similar in all groups (a) Relative RyR2 mRNA levels normalized to GAPDH mRNA in sham, male, OVX, and OVX + E2. (n = 3 mice). b Relative SERCA2a mRNA levels normalized to GAPDH mRNA in sham, male, OVX, and OVX + E2. (n = 3 mice). c Relative PLB and SLN mRNA levels normalized to GAPDH mRNA in sham, male, OVX, and OVX + E2. (n = 3 mice). *P < 0.05, **P < 0.01, and ***P < 0.001. All data are presented as mean ± S.E.M

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