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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes

Fig. 4

Sex differences in basal mRNA level of PDE3A, PDE3B, PDE4A, PDE4B, and PDE4D are mediated by E2. GAPDH levels were similar in all groups (a) PDE4A mRNA level in sham, male, OVX, and OVX + E2. (n = 3 mice). b PDE4B mRNA level in sham, male, OVX, and OVX + E2. (n = 3 mice). c PDE4D mRNA level in sham, male, OVX, and OVX + E2. (n = 3 mice). d PDE3A mRNA level in sham, male, OVX, and OVX + E2. (n = 3 mice). e PDE3B mRNA level in sham, male, OVX, and OVX + E2. (n = 3 mice). *P < 0.05, **P < 0.01, and ***P < 0.001. All data are presented as mean ± S.E.M

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