Skip to main content
Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes

Fig. 1

Influence of estrogen on sex differences in basal contraction. a, Comparison of fractional shortening in male, sham, OVX and OVX + 17β-estradiol (E2) myocytes, n = 12 cell/4 mice. b, Comparison of Ca2+ transient amplitude (Fura-2 ratio) in male, sham, OVX and OVX + E2 myocytes, n = 12 cell/4 mice. c The representative Ca2+ transient traces. d, Correlation between plasma 17β-estradiol and basal contraction amplitude, r = 0.8584, P < 0.05, n = 21. e, Effects of estrogen receptor agonists and antagonists on contraction. f, Effects of estrogen receptor agonists and antagonists on intracellular calcium amplitude. All data are presented as mean ± S.E.M. *P < 0.05 and **P < 0.01

Back to article page
\