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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells

Fig. 1

PAK1 is frequently overexpressed in ESCC. Expressions of PAK1 were detected by qRT-qPCR (a) and western blotting analysis (b) in one immortalized esophageal epithelial cell line (Het-1A) and seven ESCC cell lines. Data for qRT-qPCR represent the mean ± SD of six replicates. c Representative IHC micrographs (left) and summary bar chart (right) of PAK1 protein expression in ESCC tissues (all ESCC cases had matched adjacent normal tissues). Scale bars, 50 μm. d PAK1 mRNA expression was calculated from two data sets, GSE23400 (N = 53 pairs) and GSE20347 (N = 17 pairs), both of which were examined cDNA microarray from primary ESCC and paired normal tissues). ***P < 0.001 by paired Student’s t test

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