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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model

Fig. 7

Plasmodium infection inhibits tumor cytokines and chemokines secretions through exosomes-like vesicles. To determine whether or not cell-to-cell contact was required for the inhibition of tumor cytokines, we co-cultured LLC cells with either infected RBCs (Li), uninfected RBCs (LRB), exosomes isolated from uninfected mice (LN), exosomes isolated from Py-infected mice (LP), exosomes isolated from tumor-bearing mice infected with Py (LLP), or plasma from Py-infected mice after exosomes have been isolated (LPL). Cells were cultured for either 24 or 48 h and subsequently harvested for RNA extraction and QPCR analysis. Our QPCR results suggest that infected RBCs does not communicate with tumor cells through cell-to-cell contact. Exosome-like vesicles significantly inhibited tumor release of GMCSF(a), IL-10(b), IL-6(c), CCL-17(d), and CCL-22(e) at the mRNA levels

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Cell Communication and Signaling

ISSN: 1478-811X