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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model

Fig. 4

Effects of Plasmodium infection on MDSC signal transduction and downstream protein expression. The expression levels of pSTAT1, pSTAT3, pSTAT5, pSTAT6, NF-κB, Survivin, and S100A9 were assessed by qRT-PCR and western blot analysis. a The protein expression levels of pSTAT1, pSTAT3, pSTAT5, pSTAT6, NF-KB, Survivin and S100A9 in MDSCs from the infected and control mice, as determined by western blotting. b, c qRT-PCR analysis of Survivin and S100A9 expression of the sorted MDSCs. d The protein expression of pSTAT3 in the two MDSC subsets was assessed. (e) Purity of the sorted MDSCs. β-Actin was used as a loading control for both the qRT-PCR and western blot analysis. *P < 0.05. MM, monocytic MDSC; PM, polymorphonuclear MDSC

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Cell Communication and Signaling

ISSN: 1478-811X