Skip to main content
Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model

Fig. 3

Expression levels of key MDSC- and Treg-recruiting cytokines and chemokines in the tumor tissues assessed by qRT-PCR and western blotting. The relative mRNA expression levels of GM-CSF (a), G-CSF (b), M-CSF (c), IL-1β (d), VEGF (e), IL-6 (f), IFN-g (g) IL-14 (h), IL-13 (i), CCL-17 (i) TGF-β (j), CCL-17 (k), and CCL-22 (l) in the tumor tissues of Py-infected tumor-bearing mice compared with those of the control mice. Western blot results of CCR4 protein expression in the tumor tissues (m). β-Actin was used as a loading control. Plasmodium infection significantly decreased the relative mRNA levels of key MDSC and Treg cytokines and chemokines in the tumor tissues of Py-infected tumor-bearing mice compared to the control mice

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X