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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model

Fig. 1

Downregulation of the population of MDSCs in the tumor microenvironment by Plasmodium. a Gating protocol for the identification of MDSC subsets. b Gated polymorphonuclear and monocytic MDSCs in the tumor tissues of uninfected tumor-bearing mice (LR, control). c Gated polymorphonuclear and monocytic MDSCs in the tumor tissues of Py-infected tumor-bearing mice (treated, LP). d Comparison of the total MDSC population in the tumor tissues of both the treated and the control groups. e The relative proportions of polymorphonuclear and monocytic MDSC subsets in the tumor tissues of tumor-bearing mice treated with infected and uninfected RBCs. f Tumors harvested from tumor-bearing mice treated or untreated with Plasmodium 18 days after tumor inoculation. A total of 50,000 live events was recorded and analyzed per sample. The average number of MDSCs gated out were 2000 cells and 5000 cells for (LP) and (LR) respectively

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Cell Communication and Signaling

ISSN: 1478-811X