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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells

Fig. 8

DisBa-01 colocalizes with VEGFR2 and αvβ3. a Representative confocal images of triple stained HUVECs cells cultured in FN coated plates: αvβ3 (Green), DisBa-01 (Red), and VEGFR2 (Blue) in separated and merged channels. White = triple colocalization. b Orthogonal view of Z-stack projections showing the colocalization of αvβ3 integrin, DisBa-01 and VEGFR2 receptor. c Measurement of colocalization coefficients (tM1 and Pearson) of DisBa-01 with VEGFR2 and αvβ3. Results represent the average of n = 10 cells from three independent experiments. Slides were analyzed by confocal microscopy and pictures were taken using 63x magnification. Scale bar = 5 μm

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Cell Communication and Signaling

ISSN: 1478-811X