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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation

Fig. 7

FKB selectively inhibits the growth of RB deficient cells compared to RB wild type cells. a, mRNA expression of Rb and Skp2 was analyzed via RT-PCR and qPCR in MEF wild-type and Rb−/− cell lines. b, Mouse embryonic fibroblasts (MEFs) and c, mouse prostate epithelial cells (MPECs), wild-type and Rb−/−, were treated with 0.1% DMSO or indicated concentration of FKB for 72 h. Cell viabilities were measured via MTT assays

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Cell Communication and Signaling

ISSN: 1478-811X