Fig. 3
From: Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS
Targeting the synergistic interaction between HFD and oncogenic KRAS to inhibit aerobic glycolysis. Previous studies have shown that oncogenic KRAS drives aerobic glycolysis to facilitate PDAC development, and thus, targeting oncogenic KRAS downstream pathways responsible for aerobic glycolysis or directly inhibiting aerobic glycolysis has been proposed as therapeutic strategies to hamper PDAC development. In this study, we demonstrate that chronic consumption of obesogenic high-fat diet (HFD), but not carbohydrate-rich diet, synergizes with oncogenic KRAS to induce heightened aerobic glycolysis in PDAC development. Therefore, targeted inhibition of this synergistic cooperation would be a novel approach to inhibiting aerobic glycolysis for the prevention and treatment of PDAC