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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: A signalling cascade involving receptor-activated phospholipase A2, glycerophosphoinositol 4-phosphate, Shp1 and Src in the activation of cell motility

Fig. 8

Schematic representation of the signalling cascade involved in the formation of GroPIns4P in NIH3T3 cells. In NIH3T3 cells, activation of the EGF receptor (EGFR) can lead to activation of cPLA2α through the involvement of MEK kinase. cPLA2α activation results in hydrolysis of PtdIns4P and release of GroPIns4P, which binds to Shp1 and promotes its association with Src. Once activated Src triggers a signalling cascade culminating with the formation of Tiam/Rac complex at the plasma membrane and consequent formation membrane ruffles with stimulation of cell motility. See text for details

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Cell Communication and Signaling

ISSN: 1478-811X