Skip to main content
Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer

Fig. 3

Lovastatin potentiates ErbB2 kinase inhibitors to suppress ErbB2-positive breast cancer cells. a SKBR3, AU565, and HCC1954 cells were treated with lovastatin (lova, 40 μM), lapatinib (lap, 200 nM), neratinib (ner, 200 nM), or combinations as indicated for 24 h. Cell viability was then examined via MTT assays. Column charts show data from 3 independent experiments and error bars represent the standard error of the mean (SEM), with * and ** indicating p < 0.05 and p < 0.01, respectively. b breast cancer cells were treated as above and processed for double staining with Annexin V and propidium iodide (PI) to inspect apoptotic populations. c column charts show the quantitation of apoptotic cells with positive Annexin V staining (right two quadrants) from b

Back to article page