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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target

Fig. 6

Inhibition of the CDK4 by palbociclib reduces tumor burden in vivo. Six-week-old female BALB/c nu/nu mice were intratibially injected with SW1353 stably transfected with luciferase in PBS. From day 1 post-cell inoculation, animals were treated with the vehicle (PBS) or palbociclib (75 mg/kg/day or 150 mg/kg/day) until day 30. (a) Representative live images and (b) CDK4 IHC staining of decalcified bones of the mice treated with vehicle (above) or palbociclib (below) at day 30. (c) BLI signals were analyzed and quantified using Living Image 3.0 from week 1 to 4 post cell inoculation. (d) Evaluation of cachexia (relative body weight)

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Cell Communication and Signaling

ISSN: 1478-811X