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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target

Fig. 3

CDK4 inhibition induced by palbociclib decreases cell proliferation in an Rb-dependent manner. (a and b) Human chondrosarcoma cells CS-1 and SW1353 were exposed to increasing concentrations of palbociclib for 5 days, cell viability was measured by MTT assay. (c and d) Human chondrosarcoma cells CS-1 (a) and SW1353 (b) were treated with increasing concentrations of palbociclib for 5 days, and cell growth was analyzed by cell counting. (e) Human chondrosarcoma cell lines CS-1 and SW1353 were incubated with increasing concentration of CDK4 inhibitor, palbociclib, for 48 h, and the expression of respective proteins in CDK4-Rb-apoptosis signaling pathway was examined by western blotting

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Cell Communication and Signaling

ISSN: 1478-811X